MSR1 / CD204 Antibody

MSR1 / CD204 Antibody Datasheet

MSR1 / CD204 Antibody Product Information

• Immunogen: Recombinant Mouse MSR1 / CD204 protein (Catalog#50129-M07H)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse MSR1 / CD204 (rM MSR1 / CD204; Catalog#50129-M07H; AAH03814.1; Trp 83-Val 354). Total IgG was purified by Protein A affinity chromatography.

MSR1 / CD204 Antibody Usage Guide

• Specificity: Mouse MSR1 / CD204
• Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse MSR1 in WB.
• Direct ELISA: This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse MSR1. The detection limit for Mouse MSR1 is approximately 0.00245 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

MSR1 / CD204 Antibody Background

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type II membrane protein which contains onecollagen-like domain and oneSRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

1. Wang,L.et al., 2003, Nat Genet. 35 (2): 128-9.
2. Chen,Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev17 (4): 1001-3.
3. Shirato,K. et al., 2009,Pflugers Arch459 (1): 93-103.
4. Sun J.et al., 2006, Prostate. 66 (7): 728-37.