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>Human Cell Expressed
>Human MSLN / Mesothelin Protein (aa 296-580, Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Mesothelin Protein Datasheet
MSLN / Mesothelin Protein Price Inquiry ( Available Sizes )
MSLN / Mesothelin Protein Product Information
|Synonym :||MSLN, MPF|
A DNA sequence encoding the human MSLN (Q13421-2) (Glu296-Gly580) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
|Expression Host:||Human Cells|
MSLN / Mesothelin Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
MSLN / Mesothelin protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu|
The recombinant human MSLN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
MSLN / Mesothelin Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
MSLN / Mesothelin Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|MSLN / Mesothelin||Human||MSLN / Mesothelin (aa 296-580) Protein, Recombinant||13128-H01H|
|MSLN / Mesothelin||Human||MSLN / Mesothelin Protein, Recombinant||13128-H02H|
|MSLN / Mesothelin||Human||MSLN / Mesothelin Protein, Recombinant||13128-H08H|
MSLN / Mesothelin Protein Description
Megakaryocyte potentiating factor is a member of the mesothelin family. This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Both megakaryocyte potentiating factor and the cleaved form of mesothelin are N-glycosylated. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment. Megakaryocyte potentiating factor interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Its membrane-anchored forms may play a role in cellular adhesion.
- Chang MC. et al., 2012, Biochem J. 442 (2): 293-302.
- Nelson HH. et al., 2011, Epigenetics. 6 (8): 1029-34.
- Bournet B. et al., 2012, Pancreatology. 12 (1): 27-34.