MOG(aa30-149) Protein Price Inquiry ( Available Sizes )
MOG(aa30-149) Protein Product Information
||A DNA sequence encoding the mouse MOG (Q61885) extracellular domain (Gly 29-Thr 156) was expressed, with a C-terminal polyhistidine tag.
MOG(aa30-149) Protein QC Testing
||> 97 % as determined by SDS-PAGE.
||Please contact us for more information.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant mouse MOG comprises 138 amino acids and migrates as an approximately 16 kDa band as predicted in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS, pH5.5
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
MOG(aa30-149) Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
MOG(aa30-149) Protein Related Products & Topics
MOG(aa30-149) Protein Description
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.
- Chekhonin VP. et al., 2003, Biomed Khim. 49 (5): 411-23.
- Hilton AA. et al., 1995, J Neurochem. 65 (1): 309-18.
- Johns TG. et al., 1999, J Neurochem. 72 (1): 1-9.