MOG Protein & Antibody

Myelin Oligodendrocyte Glycoprotein

MOG Products

MOG Protein, Recombinant

Molecule	Species	Description	Cat. No
MOG	Human	MOG Protein, Recombinant	10364-H08E
MOG	Mouse	MOG (aa30-149) Protein, Recombinant	51046-M08E

MOG Antibody

Molecule	Application	Description	Cat. No
Human MOG	WB, ELISA	MOG Antibody, Rabbit PAb	10364-RP01
Human MOG	WB, ELISA	MOG Antibody, Rabbit PAb (Antigen Affinity Purified)	10364-RP02
Human MOG	WB, ELISA	MOG Antibody	10364-RP13

MOG cDNA Clone

Molecule	Species	Description	Cat. No
MOG	Human	Homo sapiens MOG transcript variant alpha1 cDNA Clone(NM_206809.2)	HG10364-M
MOG	Mouse	MOG cDNA Clone / ORF Clone	MG51046-G

MOG Related Areas

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>MOG

MOG Alternative Names

MOG, DAQB-92E24.2, MGC26137, MOGIG2 [Homo sapiens]

Mog, B230317G11Rik [Mus musculus]

MOG Background

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.

MOG Related Studies

1. Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
2. Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
3. Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.