Anti-MOG Antibody

Cat: 10364-RP02
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Anti-MOG Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-MOG Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human MOG
Immunogen
Recombinant Human MOG protein (Catalog#10364-H08E)
Preparation
Produced in rabbits immunized with purified, recombinant Human MOG (rh MOG; Catalog#10364-H08E; NP_996532.2; Gly 30-Tyr 149). MOG specific IgG was purified by human MOG affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MOG Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MOG Antibody (Rabbit Polyclonal antibody) Images
Human Myelin oligodendrocyte glycoprotein Immunohistochemistry(IHC) 3890
Immunochemical staining of human MOG in human brain with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Anti-MOG Antibody Alternative Names
Anti-BTN6 Antibody;Anti-BTNL11 Antibody;Anti-MOGIG2 Antibody;Anti-NRCLP7 Antibody
MOG Background Information

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.

Full Name
myelin oligodendrocyte glycoprotein
References
  • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
  • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
  • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MOG Antibody Mouse Monoclonal IHC-P 80425-MM04T
    Anti-MOG Antibody Rabbit Polyclonal WB,ELISA,IHC-P 80425-T56
    Anti-MOG Antibody Rabbit Polyclonal ELISA,IHC-P 51046-T24
    Anti-MOG Antibody Mouse Monoclonal ELISA 10364-MM05
    Anti-MOG Antibody Rabbit Polyclonal ELISA 10364-RP01
    Anti-MOG Antibody Rabbit Monoclonal ELISA 10364-R013
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