MMP-9 / MMP9 Protein & Antibody

Matrix Metallopeptidase 9

MMP-9 / MMP9 Products

MMP-9 / MMP9 Protein, Recombinant

Molecule	Species	Description	Cat. No
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant	10327-H08H
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant	10327-HNAH
MMP-9/MMP9	Mouse	MMP-9/MMP9 Protein, Recombinant	50560-MNAH
MMP-9/MMP9	Rat	MMP-9/MMP9 Protein, Recombinant	80049-R08H

  10327-H08H:  The specific activity is > 800 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2, (AnaSpec, Cat#27076).

  10327-HNAH:  The specific activity is > 600 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2, (AnaSpec, Cat#27076).

  80049-R08H:  The specific activity is > 1000 pmoles/min/µg. Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2, (R&D Systems, Catalog # ES010).

MMP-9 / MMP9 Antibody

Molecule	Application	Description	Cat. No
Human MMP-9/MMP9	ELISA	Mouse Monoclonal Antibody	10327-MM01
Human MMP-9/MMP9	WB	Mouse Monoclonal Antibody	10327-MM02
Human MMP-9/MMP9	ELISA	Rabbit Monoclonal Antibody	10327-RM04
Human MMP-9/MMP9	WB, ELISA	Rabbit Monoclonal Antibody	10327-RM05
Human MMP-9/MMP9	WB, ELISA	MMP-9/MMP9 Antibody, Rabbit PMb (Biotin conjugated)	10327-R043B
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody	10327-RP03
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10327-RP06
Rat MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	80049-RP02
Rat MMP-9/MMP9	WB, ELISA	MMP-9 Antibody	80049-MM04
Rat MMP-9/MMP9	WB, ELISA	MMP-9 Antibody	80049-MM05

MMP-9 / MMP9 ELISA Kit

Molecule	Application	Description	Cat. No
Human MMP-9/MMP9	ELISA	MMP-9/MMP9 ELISA Kit	SEK10327

MMP-9 / MMP9 cDNA Clone

Molecule	Species	Description	Cat. No
MMP-9/MMP9	Human	Homo sapiens MMP-9/MMP9 cDNA Clone(NM_004994.2)	HG10327-M
MMP-9/MMP9	Mouse	Mus musculus MMP-9/MMP9 cDNA Clone	MG50560-M
MMP-9/MMP9	Rat	Rattus norvegicus MMP-9/MMP9 cDNA Clone	RG80049-M

MMP-9 / MMP9 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Matrix Metalloproteinase>>MMP-9/MMP9

Cancer>>Angiogenesis>>Matrix Metalloproteinase>>MMP-9/MMP9

Cancer>>Cancer Biomarkers>>MMP-9/MMP9

MMP-9 / MMP9 Alternative Names

MMP-9, MMP9, CLG4B, GELB, MANDP2 [Homo sapiens]

MMP-9, Mmp9, pro-MMP-9, B/MMP9, Clg4b, RP23-61O3.10, AW743869 [Mus musculus]

MMP-9 / MMP9 Related Products

Protein Products

Molecule	Species	Description
MMP-1/MMP1	Human	MMP-1/MMP1 Protein, Recombinant
MMP-2/MMP2	Human	MMP-2/MMP2 Protein, Recombinant
MMP-7/MMP7	Human	MMP-7/MMP7/Fc Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Mouse	MMP-8/MMP8 Protein, Recombinant
MMP-12/MMP12	Human	MMP-12/MMP12 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
MMP-1/MMP1	Human	Homo sapiens MMP-1/MMP1 cDNA Clone(NM_002421.3)
MMP-2/MMP2	Human	Homo sapiens MMP-2/MMP2 transcript variant 1 cDNA Clone(NM_004530.4)
MMP-3/MMP3	Human	Homo sapiens MMP-3/MMP3 cDNA Clone(NM_002422.3)
MMP-7/MMP7	Human	Homo sapiens MMP-7/MMP7 cDNA Clone(NM_002423.3)
MMP-7/MMP7	Mouse	Mus musculus MMP-7/MMP7 cDNA Clone
MMP-8/MMP8	Human	Homo sapiens MMP-8/MMP8 DNA ORF Clone(NM_002424.2)
MMP-8/MMP8	Mouse	Mus musculus MMP-8/MMP8 cDNA Clone
MMP-10/MMP10	Human	Homo sapiens MMP-10/MMP10 cDNA Clone(NM_002425.1)
MMP-12/MMP12	Human	Homo sapiens MMP-12/MMP12 cDNA Clone(NM_002426.3)
MMP-13/MMP13	Human	Homo sapiens MMP-13/MMP13 cDNA Clone
MMP-15/MMP15	Human	Homo sapiens MMP-15/MMP15 cDNA Clone
MMP-16/MMP16	Human	Homo sapiens MMP-16/MMP16 cDNA Clone

MMP-9 / MMP9 Background

Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent of the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. In addition, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.

MMP-9 / MMP9 Related Studies

1. St-Pierre Y, et al. (2003) Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. Curr Drug Targets Inflamm Allergy. 2(3): 206-15.
2. St-Pierre Y, et al. (2004) Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets. 8(5): 473-89.
3. Chakrabarti S, et al. (2005) Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res. 31(6): 599-621.