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MMP-9 / CLG4B Antibody, Rabbit PAb

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Human MMP-9 Antibody Product Information
Immunogen:Recombinant Human MMP-9 protein (Catalog#10327-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human matrix metallopeptidase 9 (rhMMP9; Catalog#10327-H08H; aa 1-707; NP_004985.2). Total IgG was purified by Protein A affinity chromatography.
Human MMP-9 Antibody Usage Guide
Specificity:Human MMP9 / CLG4B
Application:ELISA

ELISA: 0.25-0.5 μg/mL

This antibody can be used at 0.25-0.5 μg/mL with the appropriate secondary reagents to detect Human MMP9. The detection limit for Human MMP9 is approximately 0.6 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other MMP-9 Antibody Products
Reactivity: Human  
Application: ELISA  
    10327-MM01-200
    10327-MM01-50
    10327-MM01-100
    200 µg 
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10327-RM04-50
      10327-RM04-100
      50 µg 
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      Reactivity: Human  
      Application: ELISA  
        10327-RM05-50
        10327-RM05-100
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        Reactivity: Human  
        Application: ELISA  
          10327-RP06-200
          10327-RP06-50
          10327-RP06-100
          200 µg 
          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: ELISA  
            10327-R043B-50
            10327-R043B-100
            50 µg 
            100 µg 
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            Reactivity: Mouse  
            Application: ELISA  
              50560-RP01-100
              50560-RP01-400
              50560-RP01-200
              100 µg 
               
              200 µg 
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              Reactivity: Mouse  
              Application: ELISA  
                50560-T16-50
                50560-T16-100
                50560-T16-200
                50 µg 
                100 µg 
                200 µg 
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                Reactivity: Rat  
                Application: ELISA  
                  80049-RP02-50
                  80049-RP02-100
                  80049-RP02-200
                  50 µg 
                  100 µg 
                  200 µg 
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                  Reactivity: Rat  
                  Application: ELISA  
                    80049-MM04-50
                    80049-MM04-100
                    80049-MM04-200
                    50 µg 
                    100 µg 
                    200 µg 
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                    Reactivity: Rat  
                    Application: ELISA  IHC-P  
                    • Slide 1
                    80049-T24-50
                    80049-T24-100
                    80049-T24-200
                    50 µg 
                    100 µg 
                    200 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80049-RP01-100
                      80049-RP01-200
                      80049-RP01-400
                      100 µg 
                      200 µg 
                       
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                      MMP9/MMP-9/CLG4B Background

                      Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent of the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. In addition, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.

                      Human MMP9/MMP-9/CLG4B References
                    • St-Pierre Y, et al. (2003) Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. Curr Drug Targets Inflamm Allergy. 2(3): 206-15.
                    • St-Pierre Y, et al. (2004) Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets. 8(5): 473-89.
                    • Chakrabarti S, et al. (2005) Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res. 31(6): 599-621.
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                      Catalog: 10327-RP03-400
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                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"