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MMP-9 / CLG4B Antibody, Rabbit MAb

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    Human MMP-9 Antibody Product Information
    Immunogen:Recombinant Human MMP9 protein (Catalog#10327-H08H)
    Clone ID:43
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human matrix metallopeptidase 9 (rh MMP9; Catalog#10327-H08H; Met 1-Asp 707; NP_004985.2).
    Other MMP-9 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10327-MM01-200
      10327-MM01-50
      10327-MM01-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10327-RP03-400
        10327-RP03-100
        10327-RP03-200
         
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10327-RM05-50
          10327-RM05-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10327-RP06-200
            10327-RP06-50
            10327-RP06-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: ELISA  
              10327-R043B-50
              10327-R043B-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50560-RP01-100
                50560-RP01-400
                50560-RP01-200
                100 µg 
                 
                200 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  50560-T16-50
                  50560-T16-100
                  50560-T16-200
                  50 µg 
                  100 µg 
                  200 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80049-RP02-50
                    80049-RP02-100
                    80049-RP02-200
                    50 µg 
                    100 µg 
                    200 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80049-MM04-50
                      80049-MM04-100
                      80049-MM04-200
                      50 µg 
                      100 µg 
                      200 µg 
                      Add to Cart
                      Reactivity: Rat  
                      Application: ELISA  
                        80049-RP01-100
                        80049-RP01-200
                        80049-RP01-400
                        100 µg 
                        200 µg 
                         
                        Add to Cart
                        MMP9/MMP-9/CLG4B Background

                        Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent of the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. In addition, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.

                        Human MMP9/MMP-9/CLG4B References
                      • St-Pierre Y, et al. (2003) Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. Curr Drug Targets Inflamm Allergy. 2(3): 206-15.
                      • St-Pierre Y, et al. (2004) Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets. 8(5): 473-89.
                      • Chakrabarti S, et al. (2005) Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res. 31(6): 599-621.
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                        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"