Anti-MMP-8 Antibody

Cat: 10254-RP01
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Anti-MMP-8 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-MMP-8 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human MMP-8
Immunogen
Recombinant Human MMP8 protein (Catalog#10254-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human MMP8 (rh MMP8; Catalog#10254-H08H; NP_002415.1; Met 1-Gly 467). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MMP-8 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MMP-8 Antibody (Rabbit Polyclonal antibody) Images
Human MMP-8 / MMP8 Western blot (WB) 13151

Anti-MMP8 rabbit polyclonal antibody at 1:500 dilution

Lane A: 293T Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:53 kDa

Observed band size:55 kDa

(We are unsure as to the identity of these extra bands.)

Anti-MMP-8 Antibody Alternative Names
Anti-CLG1 Antibody;Anti-HNC Antibody;Anti-MMP-8 Antibody;Anti-PMNL-CL Antibody
MMP-8 Background Information

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. Neutrophil collagenase, also known as Matrix metalloproteinase-8, MMP-8, and CLG1, is a member of the peptidase M10A family. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumour may have a protective effect against lymph node metastasis. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.

Full Name
matrix metallopeptidase 8
References
  • Hasty K.A., et al.,(1990), Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J. Biol. Chem. 265:11421-11424.
  • Blaeser J., et al., (1991), Mercurial activation of human polymorphonuclear leucocyte procollagenase.Eur. J. Biochem. 202:1223-1230.
  • Blaeser J., et al.,(1991), Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur. J. Biochem. 202:1223-1230.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MMP-8 Antibody Rabbit Polyclonal ELISA 50493-RP01
    Anti-MMP-8 Antibody Rabbit Polyclonal ELISA 50493-T16
    Anti-MMP-8 Antibody Rabbit Polyclonal WB,ELISA 10254-RP02
    Anti-MMP-8 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10254-R102
    Anti-MMP-8 Antibody Rabbit Monoclonal ELISA(Cap) 10254-R206
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