MMP-3 (MMP3)

Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

MMP-3 (MMP3) Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Matrix Metalloproteinase>>MMP-3/MMP3

Cancer>>Angiogenesis>>Matrix Metalloproteinase>>MMP-3/MMP3

Cancer>>Cancer Biomarkers>>MMP-3/MMP3

MMP-3 (MMP3) Alternative Names

CHDS6, MMP-3, SL-1, STMY, STMY1, STR1, matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metalloproteinase-3; proteoglycanase; stromelysin-1; transin-1 [Homo sapiens]

SLN-1, SLN1, STR-1, Stmy1, Str1 , EMS-2; MMP-3; SL-1; matrix metalloproteinase 3; matrix metalloproteinase-3; progelatinase; stromelysin 1; stromelysin-1; transin-1 [Mus musculus]

Summaries for MMP-3 (MMP3)

Entrez Gene summary for MMP-3 (MMP3):

OMIM - description for MMP-3 (MMP3):

Human fibroblast stromelysin (also called transin or matrix metalloproteinase-3) is a proteoglycanase closely related to collagenase (MMP1; 120353) with a wide range of substrate specificities. It is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix (Sellers and Murphy, 1981). Stromelysin is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen.

Wikipedia summary for MMP-3 (MMP3):

Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.MMP-3 has an estimated molecular weight of 54 kDa.

Human MMP-3 (MMP3) Protein General Information

 

• Protein names: Recommended name: Stromelysin-1 Short name=SL-1
• Sequence length: 477 AA.
• Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
• Sequence similarities: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
• Subcellular location: Secreted › extracellular space › extracellular matrix
• Involvement in disease: Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:614466]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions

General information above from UniProt

Function for MMP-3 (MMP3) Protein

UniProtKB:

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Genatlas:

• activates a number of pro-MMPs
• critical role for the generation of the fully active MMP1
• MMP-3 (MMP3) is involved in cell migration, mammary epithelial cell apoptosis and alveolar formation, mammary epithelial-mesenchymal cell conversion, generation of angiostatin-like fragment
• MMP-3 (MMP3) is involved in enhanced collagen affinity, release of bFGF, increased bioavailability of IGF1, TGF beta and cell, pro/antiinflammatory roles
• MMP-3 (MMP3) inhibites breast tumor cell invasion by a mechanism involving plasminogen degradation to fragments that limit plasminogen activation and the degradation of laminin
• MMP-3 (MMP3) is involved in disrupted cell aggregation and increased cell invasion
• signaling proteinase from apoptotic neuronal cells that activates microglia, and may play a major role in degenerative brain disorders, such as Parkinson's disease
• MMP-3 (MMP3) has a function as a trans regulator of connective tissue growth factor (CTGF)
• MMP-3 (MMP3) plays a role in the ER stress-induced apoptosis
• is both a direct transcriptional target and a necessa
• involvement in digestion of SNCA in dopaminergic neurons, playing a pivotal role in the progression of Parkinson disease through modulation of SNCA in aggregation, Lewy body formation, and neurotoxicity
• MMP-3 (MMP3) may contribute to the breakdown of articular cartilage during arthritis
• MMP-3 (MMP3) role in the pathogenesis of idiopathic pulmonary fibrosis, through activation of beta-catenin signaling and induction of epithelial-mesenchymal transition

Homology for human MMP-3 (MMP3)

• homolog to murine Mmp3

Phenotype Information for MMP-3 (MMP3)

• Gene/Locus: MMP3, STMY1, CHDS6
• Phenotype: {Coronary heart disease, susceptibility to, 6}

Phenotype Information for MMP-3 (MMP3) from OMIM (Online Mendelian Inheritance in Man)