MMP-2 / MMP2 Protein & Antibody

Matrix Metallopeptidase 2

MMP-2 / MMP2 Products

MMP-2 / MMP2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MMP-2/MMP2	Human	MMP-2/MMP2 Protein, Recombinant, with Native	10082-HNAH

MMP-2 / MMP2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human MMP-2/MMP2	WB, ELISA	MMP-2 Antibody	10082-MM05
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb	10082-RP01
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb (Antigen Affinity Purified)	10082-RP02
Human MMP-2/MMP2	WB	MMP-2 Antibody	10082-R026
Human MMP-2/MMP2	ELISA	MMP-2 Antibody	10082-R029

MMP-2 / MMP2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MMP-2/MMP2	Human	Homo sapiens MMP-2/MMP2 transcript variant 1 cDNA Clone	HG10082-M

MMP-2 / MMP2 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Matrix Metalloproteinase>>MMP-2/MMP2

Cancer>>Angiogenesis>>Matrix Metalloproteinase>>MMP-2/MMP2

Cancer>>Cancer Biomarkers>>MMP-2/MMP2

MMP-2 / MMP2 Alternative Names

MMP-2, MMP2, MMP-II, CLG4, CLG4A, MONA, TBE-1 [Homo sapiens]

MMP-2, Mmp2, Clg4a, GelA [Mus musculus]

MMP-2 / MMP2 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
MMP-1/MMP1	Human	MMP-1/MMP1 Protein, Recombinant
MMP-7/MMP7	Human	MMP-7/MMP7/Fc Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Mouse	MMP-8/MMP8 Protein, Recombinant
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Mouse	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Rat	MMP-9/MMP9 Protein, Recombinant
MMP-12/MMP12	Human	MMP-12/MMP12 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human MMP-9/MMP9	ELISA	Mouse Monoclonal Antibody
Human MMP-9/MMP9	WB	Mouse Monoclonal Antibody
Human MMP-9/MMP9	ELISA	Rabbit Monoclonal Antibody
Human MMP-9/MMP9	WB, ELISA	Rabbit Monoclonal Antibody
Human MMP-9/MMP9	WB, ELISA	MMP-9/MMP9 Antibody, Rabbit PMb (Biotin conjugated)
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
MMP-1/MMP1	Human	Homo sapiens MMP-1/MMP1 cDNA Clone(NM_002421.3)
MMP-3/MMP3	Human	Homo sapiens MMP-3/MMP3 cDNA Clone(NM_002422.3)
MMP-7/MMP7	Human	Homo sapiens MMP-7/MMP7 cDNA Clone(NM_002423.3)
MMP-7/MMP7	Mouse	Mus musculus MMP-7/MMP7 cDNA Clone
MMP-8/MMP8	Human	Homo sapiens MMP-8/MMP8 DNA ORF Clone(NM_002424.2)
MMP-8/MMP8	Mouse	Mus musculus MMP-8/MMP8 cDNA Clone
MMP-9/MMP9	Human	Homo sapiens MMP-9/MMP9 cDNA Clone(NM_004994.2)
MMP-9/MMP9	Mouse	Mus musculus MMP-9/MMP9 cDNA Clone
MMP-9/MMP9	Rat	Rattus norvegicus MMP-9/MMP9 cDNA Clone
MMP-10/MMP10	Human	Homo sapiens MMP-10/MMP10 cDNA Clone(NM_002425.1)
MMP-12/MMP12	Human	Homo sapiens MMP-12/MMP12 cDNA Clone(NM_002426.3)
MMP-13/MMP13	Human	Homo sapiens MMP-13/MMP13 cDNA Clone
MMP-15/MMP15	Human	Homo sapiens MMP-15/MMP15 cDNA Clone
MMP-16/MMP16	Human	Homo sapiens MMP-16/MMP16 cDNA Clone

MMP-2 / MMP2 Background

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

MMP-2 / MMP2 Related Studies

1. Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
2. Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
3. Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.