Anti-MMP-2 Antibody

Cat: 10082-RP02
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All MMP-2 Reagents
Anti-MMP-2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-MMP-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human MMP-2
Immunogen
Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
Preparation
Produced in rabbits immunized with purified, recombinant Human MMP2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys 660). MMP-2 specific IgG was purified by human MMP-2 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MMP-2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MMP-2 Antibody Alternative Names
Anti-CLG4 Antibody;Anti-CLG4A Antibody;Anti-MMP-2 Antibody;Anti-MMP-II Antibody;Anti-MONA Antibody;Anti-TBE-1 Antibody
MMP-2 Background Information

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

Full Name
matrix metallopeptidase 2
References
  • Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
  • Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
  • Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MMP-2 Antibody Rabbit Polyclonal WB,IP 52740-T36
    Anti-MMP-2 Antibody Rabbit Polyclonal ELISA 52740-RP01
    Anti-MMP-2 Antibody Rabbit Monoclonal ELISA 10082-R029
    Anti-MMP-2 Antibody Mouse Monoclonal WB,ELISA 10082-MM05
    Anti-MMP-2 Antibody Rabbit Monoclonal WB 10082-R026
    Anti-MMP-2 Antibody Rabbit Polyclonal ELISA 10082-RP01
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