Anti-MMP-2 Antibody

Cat: 10082-RP01

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Anti-MMP-2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-MMP-2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human MMP-2
Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
Produced in rabbits immunized with purified, recombinant Human MMP2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys 660). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MMP-2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MMP-2 Antibody Alternative Names
Anti-CLG4 Antibody;Anti-CLG4A Antibody;Anti-MMP-2 Antibody;Anti-MMP-II Antibody;Anti-MONA Antibody;Anti-TBE-1 Antibody
MMP-2 Background Information

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

Full Name
matrix metallopeptidase 2
  • Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
  • Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
  • Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MMP-2 Antibody Rabbit Polyclonal WB,IP 52740-T36
    Anti-MMP-2 Antibody Rabbit Polyclonal ELISA 52740-RP01
    Anti-MMP-2 Antibody Rabbit Monoclonal ELISA 10082-R029
    Anti-MMP-2 Antibody Mouse Monoclonal WB,ELISA 10082-MM05
    Anti-MMP-2 Antibody Rabbit Monoclonal WB 10082-R026
    Anti-MMP-2 Antibody Rabbit Polyclonal ELISA 10082-RP02
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