Quick Order

MMP-2 / CLG4A Antibody, Rabbit PAb

    DatasheetReviewsRelated ProductsProtocols
    Human MMP-2 Antibody Product Information
    Immunogen:Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Human MMP2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys 660). Total IgG was purified by Protein A affinity chromatography .
    Other MMP-2 Antibody Products
    Reactivity: Human  
    Application: ELISA  WB  IP  
    • Slide 1
    • Slide 1
    10082-RP02-200
    10082-RP02-50
    10082-RP02-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: WB  
    • Slide 1
    10082-R026-100
    10082-R026-50
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10082-R029-50
      10082-R029-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
      • Slide 1
      10082-MM05-200
      10082-MM05-50
      10082-MM05-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        52740-RP01-400
        52740-RP01-200
        52740-RP01-100
         
        200 µg 
        100 µg 
        Add to Cart
        MMP2/MMP-2/CLG4A Background

        Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

        Human MMP2/MMP-2/CLG4A References
      • Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
      • Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
      • Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.
      • Product nameProduct name
        Size / Price
        Catalog: 10082-RP01-100
        List Price: 
        Price:      (You Save: )

        Datasheet & Documentation

        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"