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MMP-14/MMP14  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-14/MMP14 Related Area

MMP-14/MMP14 Related Pathways

    MMP-14/MMP14 Summary & Protein Information

    MMP-14/MMP14 Background

    Catalytic activity: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
    Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    Subunit structure: Interacts (via C-terminal cytoplasmic tail) with BST2. {ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:9724659}.
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
    Tissue specificity: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
    Induction: Up-regulated by NANOS1. {ECO:0000269|PubMed:18223680}.
    Post-translational: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.; Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
    Involvement in disease: DISEASE: Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269|PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-14/MMP14 Alternative Name

    MMP-14/MMP14 Related Studies

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