MMP-1 / MMP1 Protein

Matrix Metallopeptidase 1

MMP-1 / MMP1 Products

MMP-1 / MMP1 Protein, Recombinant

Molecule	Species	Description	Cat. No
MMP-1/MMP1	Human	MMP-1/MMP1 Protein, Recombinant	10532-H08H

  10532-H08H:  The specific activity is > 70 pmoles / min / µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2, AnaSpec Cat#27076.

MMP-1 / MMP1 cDNA Clone

Molecule	Species	Description	Cat. No
MMP-1/MMP1	Human	Homo sapiens MMP-1/MMP1 cDNA Clone(NM_002421.3)	HG10532-M

MMP-1 / MMP1 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Matrix Metalloproteinase>>MMP-1/MMP1

Cancer>>Angiogenesis>>Matrix Metalloproteinase>>MMP-1/MMP1

MMP-1 / MMP1 Alternative Names

MMP1 , CLG, CLGN [Homo sapiens]

Mmp1, Clg, MMP-13, Mmp13 [Mus musculus]

MMP-1 / MMP1 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
MMP-2/MMP2	Human	MMP-2/MMP2 Protein, Recombinant
MMP-7/MMP7	Human	MMP-7/MMP7/Fc Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Human	MMP-8/MMP8 Protein, Recombinant
MMP-8/MMP8	Mouse	MMP-8/MMP8 Protein, Recombinant
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Human	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Mouse	MMP-9/MMP9 Protein, Recombinant
MMP-9/MMP9	Rat	MMP-9/MMP9 Protein, Recombinant
MMP-12/MMP12	Human	MMP-12/MMP12 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb
Human MMP-8/MMP8	WB, ELISA	MMP-8/MMP8 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human MMP-9/MMP9	ELISA	Mouse Monoclonal Antibody
Human MMP-9/MMP9	WB	Mouse Monoclonal Antibody
Human MMP-9/MMP9	ELISA	Rabbit Monoclonal Antibody
Human MMP-9/MMP9	WB, ELISA	Rabbit Monoclonal Antibody
Human MMP-9/MMP9	WB, ELISA	MMP-9/MMP9 Antibody, Rabbit PMb (Biotin conjugated)
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody
Human MMP-9/MMP9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
MMP-2/MMP2	Human	Homo sapiens MMP-2/MMP2 transcript variant 1 cDNA Clone(NM_004530.4)
MMP-3/MMP3	Human	Homo sapiens MMP-3/MMP3 cDNA Clone(NM_002422.3)
MMP-7/MMP7	Human	Homo sapiens MMP-7/MMP7 cDNA Clone(NM_002423.3)
MMP-7/MMP7	Mouse	Mus musculus MMP-7/MMP7 cDNA Clone
MMP-8/MMP8	Human	Homo sapiens MMP-8/MMP8 DNA ORF Clone(NM_002424.2)
MMP-8/MMP8	Mouse	Mus musculus MMP-8/MMP8 cDNA Clone
MMP-9/MMP9	Human	Homo sapiens MMP-9/MMP9 cDNA Clone(NM_004994.2)
MMP-9/MMP9	Mouse	Mus musculus MMP-9/MMP9 cDNA Clone
MMP-9/MMP9	Rat	Rattus norvegicus MMP-9/MMP9 cDNA Clone
MMP-10/MMP10	Human	Homo sapiens MMP-10/MMP10 cDNA Clone(NM_002425.1)
MMP-12/MMP12	Human	Homo sapiens MMP-12/MMP12 cDNA Clone(NM_002426.3)
MMP-13/MMP13	Human	Homo sapiens MMP-13/MMP13 cDNA Clone
MMP-15/MMP15	Human	Homo sapiens MMP-15/MMP15 cDNA Clone
MMP-16/MMP16	Human	Homo sapiens MMP-16/MMP16 cDNA Clone

MMP-1 / MMP1 Background

MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

MMP-1 / MMP1 Related Studies

1. Gross J, et al. (1962) Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay. Proceedings of the National Academy of Sciences. 48(6):1014-22.
2. Pendas, et al. (1996) Fine Physical Mapping of the Human Matrix Metalloproteinase Genes Clustered on Chromosome 11q22.3. Genomics. 37(2):266-8.
3. Brinckerhoff C E, et al. (1987) Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. Journal of Clinical Investigation. 79(2):542-6.