MIF Protein

Macrophage migration inhibitory factor

MIF Products

MIF Protein, Recombinant

Molecule	Species	Description	Cat. No
MIF	Human	MIF Protein, Recombinant	10246-H08H
MIF	Mouse	MIF Protein, Recombinant	50066-M08H
MIF	Mouse	MIF Protein, Recombinant, Native	50066-MNAE

MIF cDNA Clone

Molecule	Species	Description	Cat. No
MIF	Human	Human MIF full length cDNA Clone / ORF Clone	HG10246-M
MIF	Mouse	Mouse MIF full length cDNA Clone / ORF Clone	MG50066-M

MIF Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>MIF

Cancer>>Cancer Biomarkers>>MIF

MIF Alternative Names

MIF, GIF, GLIF, MMIF [Homo sapiens]

Mif, GIF, Glif, MGC107654, DER6 [Mus musculus]

MIF Background

Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. MIF is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well. The significance of the role of MIF in a variety of both solid and hematologic tumors has been established. More recently, interest has increased in the role of MIF in the development of central nervous system (CNS) tumors, in which it appears to influence cell cycle control. MIF contributes to malignant disease progression on several different levels. Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread and disease-free survival. Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro. MIF plays important roles in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders.

MIF Related Studies

1. Ohkawara T, et al. (2005) Pathophysiological roles of macrophage migration inhibitory factor in gastrointestinal, hepatic, and pancreatic disorders. J Gastroenterol. 40(2): 117-22.
2. Bach JP, et al.. (2009) The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 115(10): 2031-40.
3. Rendon BE, et al.. (2009) Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation. Exp Mol Pathol. 86(3): 180-5.
4. Grieb G, et al. (2010) Macrophage migration inhibitory factor (MIF): a promising biomarker. Drug News Perspect. 23(4): 257-64.