Anti-MICB Antibody (FITC)

Cat: 10759-MM12-F
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Anti-MICB Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-MICB Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human MICB
Immunogen
Recombinant Human MICB protein (Catalog#10759-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MICB / MIC-B (rh MICB; Catalog#10759-H08H; NP_005922.2; Met 1-Gly 298) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #12
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-MICB Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MICB Antibody (FITC) (Mouse Monoclonal antibody) Images
Human MICB  Flow Cytometry (FC) 2678
Analysis of anti-MICB on HeLa cells.
Anti-MICB Antibody (FITC) Alternative Names
Anti-PERB11.2 Antibody
MICB Background Information

MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type I I receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.

Full Name
MHC class I polypeptide-related sequence B
References
  • Bauer, S. et al., 1999, Science. 285:727-729.
  • Braud, V.M. et al., 1999, Curr. Opin. Immunol. 11: 100-108.
  • Groh, V. et al., 2001, Nature Immunol. 2: 255-260.
  • Stephens, H., 2001, Trends Immunol. 22: 378-385.
  • Borrego, F. et al., 2002, Mol. Immunol. 38: 637–660.
  • Groh, V. et al., 2002, Nature. 419:734-738.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MICB Antibody (APC) Mouse Monoclonal FCM 10759-MM12-A
    Anti-MICB Antibody Rabbit Polyclonal WB,ELISA 10759-T48
    Anti-MICB Antibody Rabbit Monoclonal WB 10759-R102
    Anti-MICB Antibody Rabbit Polyclonal ELISA,IHC-P 10759-RP02
    Anti-MICB Antibody Rabbit Polyclonal WB,IHC-P 10759-T40
    Anti-MICB Antibody Rabbit Polyclonal ELISA 10759-RP01
    Anti-MICB Antibody Mouse Monoclonal ELISA,FCM 10759-MM12
    Anti-MICB Antibody (PE) Mouse Monoclonal FCM 10759-MM12-P
    Anti-MICB Antibody Rabbit Monoclonal ELISA 10759-R103
    Anti-MICB Antibody Mouse Monoclonal ELISA(Cap) 10759-MM04
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