MICA Protein & Antibody

MHC class I polypeptide-related sequence A

MICA Products

MICA Protein, Recombinant

Molecule	Species	Description	Cat. No
MICA	Human	MICA Protein, Recombinant	12302-H08H

MICA Antibody

Molecule	Application	Description	Cat. No
Human MICA	WB, ELISA	MICA Antibody (Antigen Affinity Purified)	12302-RP02

MICA cDNA Clone

Molecule	Species	Description	Cat. No
MICA	Human	MICA cDNA Clone / ORF Clone	HG12302-G

MICA Related Areas

Immunology>>Adaptive Immunity>>Major Histocompatibility Complex>>MICA

MICA Alternative Names

MICA, DAMA-345G11.2, FLJ36918, FLJ60820, MGC111087, MGC21250, MIC-A, PERB11.1 [Homo sapiens]

MICA Background

MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to MHC class I family. It is the member of the non-classical class I family that displays the greatest degree of polymorphism. The MICA protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. The Natural killer group 2D (NKG2D), a C-type lectin-like activating immunoreceptor, is a receptor of MICA, which was detected on most gammadelta T cells, CD8+ alphabeta T cells, and natural killer (NK) cells. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gammadelta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. The MICA system is a novel, avidin-free immunohistochemical detection system that provides a significant increase in sensitivity compared to traditional immunodetection systems.

MICA Related Studies

1. Choy MK, et al. (2010) MICA polymorphism: biology and importance in immunity and disease. Trends Mol Med. 16(3): 97-106.
2. Li J, et al. (2005) Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA. Cell Mol Immunol. 2(4): 253-8.
3. Mangham DC, et al. (2000) MICA-a highly sensitive and avidin-free immunohistochemical detection system. Adv Anat Pathol. 7(6): 360-4.
4. Bauer S, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285(5428): 727-9.
5. Groh V, et al. (1998) Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science. 279: 1737-40.