METTL1

METTL1 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

METTL1 Related Areas

Enzyme>>Methyltransferase>>METTL1

METTL1 Alternative Names

METTL1, C12orf1, FLJ95748, TRM8, YDL201w [Homo sapiens]

Mettl1, 2810012D02Rik [Mus musculus]

Summaries for METTL1

Entrez Gene summary for METTL1:

This METTL1 gene is similar in sequence to the S. cerevisiae YDL201w gene. METTL1 contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

Wikipedia summary for METTL1:

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.

Human METTL1 Protein General Information

 

• Protein names: tRNA (guanine-N(7)-)-methyltransferase
• Sequence length: 276 AA.
• Catalytic activity: S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
• Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
• Sequence similarities: METTL1 belongs to the methyltransferase superfamily. TrmB family.
• Post-translational modification: Phosphorylation at Ser-27 inactivates its catalytic activity but does not afffect the interaction with WDR4.
• Subunit structure: METTL1 forms a complex with WDR4.
• Subcellular location: Nucleus
• Tissue specificity: Ubiquitous.
• Sequence caution: The sequence CAA65470.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for METTL1 Protein

UniProtKB:

METTL1 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Genatlas:

• methyltransferase activity
• METTL1 is required for tRNA 7-methylguanosine-methyltransferase activity (Alexandrov 2002)
• METTL1 catalyses the 7-methylguanosine modification of tRNA (Cartlidge 2005)

Homology for human METTL1

• ortholog to yeast S. cerevisiae YDL201w
• ortholog to murine Mettl1
• homolog to Drosophila EG:22E5.4
• homolog to C.elegans W02B12.10