All METAP1 reagents are produced in house and quality controlled, including 1 METAP1 Antibody, 32 METAP1 Gene, 1 METAP1 IPKit, 2 METAP1 Lysate, 2 METAP1 Protein, 2 METAP1 qPCR. All METAP1 reagents are ready to use.
Recombinant METAP1 proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as N-human IgG1-Fc, C-His.
METAP1antibodies are validated with different applications, which are WB, ELISA, IP.
METAP1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each METAP1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
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