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> MESDC2 MESDC2
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). MESDC2 acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
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MESDC2 Related Products
MESDC2 Proteins
MESDC2 Antibodies
- Anti-Human MESDC2 Antibody, Rabbit PAb, Cat NO: 10949-RP01
- Anti-Human MESDC2 Antibody, Rabbit PAb (Antigen Affinity Purified), Cat NO: 10949-RP02
- Anti-Human MESDC2 Antibody, Cat NO: 10949-R502
MESDC2 ELISA Pair sets
MESDC2 cDNA Clones
MESDC2 Related Areas
Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>MESDC2
MESDC2 Related Pathways
MESDC2 Alternative Names
MESDC2, UNQ1911/PRO4369, BOCA, KIAA0081, MESD [Homo sapiens]
Mesdc2, 2210015O11Rik, AW537813, MGC25959, mKIAA0081 [Mus musculus]
Summaries for MESDC2
Wikipedia summary for MESDC2:
LDLR chaperone MESD is a protein that in humans is encoded by the MESDC2 gene.
Human MESDC2 Protein General Information
| Protein names |
LDLR chaperone MESD |
| Sequence length |
234 AA. |
| Domain |
The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6. The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding |
| Sequence similarities: |
MESDC2 belongs to the MESD family. |
| Sequence caution: |
The sequence BAA07640.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
| Subunit structure |
Monomer. MESDC2 interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. MESDC2 interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. |
| Subcellular location: | Endoplasmic reticulum |
General information above from UniProt
Function for MESDC2 Protein
UniProtKB:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). MESDC2 acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
Genatlas:
- MESDC2 acts as a specific chaperone for Lrp5 and Lrp6
Homology for human MESDC2
- homolog to murine Mesdc2 (87.50 pc)
- homolog to rattus Mesdc2 (85.27 pc)
- homolog to chimpanzee MESDC2 (100.00 pc)
- homolog to chicken MESDC2 (78.04 pc)
