Anti-MESDC2 Antibody

Cat: 10949-R502

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Anti-MESDC2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-MESDC2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human MESDC2
Recombinant Human MESDC2 protein (Catalog#10949-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human MESDC2 (rh MESDC2; Catalog#10949-H08H; NP_055969.1; Ala 34-Lys 230).
Monoclonal Rabbit IgG Clone #502
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MESDC2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  
IP 1-4 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MESDC2 Antibody (Rabbit Monoclonal antibody) Images
Human HSPB1/HSP 27 Immunoprecipitation(IP) 7977

MESDC2 was immunoprecipitated using:

Lane A:0.5 mg 293T Whole Cell Lysate

Lane B:0.5 mg Hela Whole Cell Lysate

Lane C:0.5 mg NIH-3T3 Whole Cell Lysate

2 µL anti-MESDC2 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-MESDC2 rabbit monoclonal antibody,at 1:500 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 26 kDa

Observed band size: 26 kDa

Human MESDC2 Western blot (WB) 13307

Anti-MESDC2 rabbit monoclonal antibody at 1:500 dilution

Lane A: HEK293 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:26 kDa

Observed band size:26 kDa

Anti-MESDC2 Antibody Alternative Names
Anti-BOCA Antibody;Anti-MESD Antibody
MESDC2 Background Information

LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.

Full Name
mesoderm development candidate 2
  • Scanlan M.J. et al., 1999, Int. J. Cancer 83:456-464.
  • Veltman,IM. et al.,2005, Hum Mol Genet  14 (14):1955-63.
  • Koduri V. et al., 2007, Biochemistry 46:6570-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-MESDC2 Antibody Rabbit Polyclonal WB,IP 10949-RP02
    Anti-MESDC2 Antibody Rabbit Polyclonal ELISA 10949-RP01
    info info
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