Anti-MESDC2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human MESD protein (Catalog#10949-H08H)
Produced in rabbits immunized with purified, recombinant Human MESDC2 (rh MESDC2; Catalog#10949-H08H; NP_055969.1; Ala 34-Lys 230). Total IgG was purified by Protein A affinity chromatography
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MESDC2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-MESDC2 Antibody Alternative Names
Anti-BOCA Antibody;Anti-MESD Antibody
MESDC2 Background Information
LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
mesoderm development candidate 2
Scanlan M.J. et al., 1999, Int. J. Cancer 83:456-464. Veltman,IM. et al.,2005, Hum Mol Genet 14 (14):1955-63. Koduri V. et al., 2007, Biochemistry 46:6570-7.