MERTK Protein (Mer Protein)

c-Mer Proto-oncogene Tyrosine Kinase

MERTK Products

MERTK Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MERTK/Mer	Human	MERTK/Mer/Fc Protein, Recombinant	10298-H03H
MERTK/Mer	Human	MERTK/Mer/Fc Protein, Recombinant	10298-HCCH
MERTK/Mer	Human	Mer / MERTK Protein, Recombinant, with GST Tag	10298-H20B1
MERTK/Mer	Mouse	MERTK/Mer Protein, Recombinant	50514-M02H
MERTK/Mer	Mouse	MERTK / MER Protein, Recombinant, with GST Tag	50514-M20B1

MERTK cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MERTK/Mer	Human	Homo sapiens MERTK/Mer cDNA Clone(NM_006343.2)	HG10298-M
MERTK/Mer	Mouse	Mus musculus MERTK/Mer cDNA Clone	MG50514-M

MERTK Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>MERTK/Mer

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>MERTK/Mer

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>MERTK/Mer

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>MERTK/Mer

MERTK Alternative Names

MERTK, MER, c-mer, MGC133349, RP38 [Homo sapiens]

Mertk, Mer, RP23-30M20.1, Eyk, Nyk [Mus musculus]

MERTK Background

&Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.

MERTK Related Studies

1. Thompson DA, et al. (2002) Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet. 70 (1): 224-9.
2. Tada A, et al. (2006) Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. Mol Vis. 12: 441-4.
3. McHenry CL, et al. (2004) MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. Invest Ophthalmol. Vis Sci. 45 (5): 1456-63.