Anti-Mer Antibody (PE)

Cat: 10298-MM01-P
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Anti-Mer Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-Mer Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Mer
Immunogen
Recombinant Human MERTK / Mer protein (Catalog#10298-H20B1)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MERTK / Mer (rh MERTK / Mer; Catalog#10298-H20B1; Q12866; Glu578-Tyr872) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG2a Clone #01
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Mer Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Mer Antibody (PE) (Mouse Monoclonal antibody) Images
Human MERTK/Mer Flow Cytometry (FC) 4837
Human MERTK(Mer) expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-MERTK(Mer). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-Mer Antibody (PE) Alternative Names
Anti-c-Eyk Antibody;Anti-c-mer Antibody;Anti-MER Antibody;Anti-RP38 Antibody;Anti-Tyro12 Antibody
Mer Background Information

&Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.

Full Name
MER proto-oncogene, tyrosine kinase
References
  • Thompson DA, et al. (2002) Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet. 70 (1): 224-9.
  • Tada A, et al. (2006) Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. Mol Vis. 12: 441-4.
  • McHenry CL, et al. (2004) MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. Invest Ophthalmol. Vis Sci. 45 (5): 1456-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Mer Antibody Mouse Monoclonal ELISA 10298-MM09
    Anti-Mer Antibody Rabbit Polyclonal ELISA 10298-RP01
    Anti-Mer Antibody Rabbit Polyclonal ELISA 10298-T16
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