Anti-Meprin alpha Antibody

Cat: 50057-R001
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All Meprin alpha Reagents
CRO Services
Product recommended

All Meprin alpha Reagents
Anti-Meprin alpha Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Meprin alpha Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse Meprin alpha
Immunogen
Recombinant Mouse MEP1A Protein (Catalog#50057-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MEP1A (rM MEP1A; Catalog#50057-M08H; NP_032611.2; Met 1-Arg 615).
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Meprin alpha Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Meprin alpha Antibody (Rabbit Monoclonal antibody) Images
Mouse MEP1A Immunohistochemistry(IHC) 3238
Immunochemical staining of mouse MEP1A in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Mouse MEP1A Immunohistochemistry(IHC) 3239
Immunochemical staining of mouse MEP1A in mouse intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-Meprin alpha Antibody Alternative Names
Anti-AI098089 Antibody;Anti-AW107200 Antibody;Anti-Mep-1 Antibody;Anti-Mep-1a Antibody;Anti-Mep1 Antibody
Meprin alpha Background Information

Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I  membrane protein which belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).

Full Name
meprin A, alpha (PABA peptide hydrolase)
References
  • Bertenshaw,GP. et al., 2002, Biol Chem. 383 (7-8):1175-83.
  • Bond, JS. et al., 2005, FEBS Lett. 579 (15): 3317-22.
  • Herzog, C. et al., 2007, Kidney Int. 71 (10): 1009-18.
  • Yura, RE. et al., 2009, Am J Physiol Renal Physiol. 296 (1): F135-44.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Meprin alpha Antibody Rabbit Polyclonal WB,ELISA 50057-RP02
    Anti-Meprin alpha Antibody Rabbit Polyclonal WB,ELISA 50057-RP01
    Anti-Meprin alpha Antibody Rabbit Monoclonal ELISA 10133-R009
    Anti-Meprin alpha Antibody Rabbit Polyclonal ELISA 10133-RP01
    Anti-Meprin alpha Antibody Rabbit Monoclonal ELISA 10133-R017
    info info
    添加购物车成功! 添加购物车失败!