MEK2 (MAP2K2, MKK2)

MEK2 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK2 activates the ERK1 and ERK2 MAP kinases.

MEK2 (MAP2K2, MKK2) Related Areas

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>MEK2/MAP2K2

Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>MEK2/MAP2K2

MEK2 (MAP2K2, MKK2) Alternative Names

MEK2, MAP2K2, MAPKK 2, MEK 2, FLJ26075, MAPKK2, MKK2, PRKMK2 [Homo sapiens]

MEK2, Map2k2, MAPKK 2, MEK 2, AA589381, MK2, Prkmk2 [Mus musculus]

Summaries for MEK2 (MAP2K2, MKK2)

Entrez Gene summary for MAP2K2:

The protein encoded by this MAP2K2 gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MEK2 is known to play a critical role in mitogen growth factor signal transduction. MEK2 phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for MEK2:

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.

Human MEK2 (MAP2K2, MKK2) Protein General Information

 

• Protein names: Dual specificity mitogen-activated protein kinase kinase 2, Short name=MAPKK 2
• Sequence length: 400 AA.
• Sequence similarities: MEK2 belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. MEK2 contains 1 protein kinase domain.
• Post-translational modification: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1
• Subunit structure: MEK2 interacts with MORG1. MEK2 interacts with SGK1.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Involvement in disease: Defects in MEK2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.

General information above from UniProt

Function for MEK2 (MAP2K2, MKK2) Protein

UniProtKB:

MEK2 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK2 activates the ERK1 and ERK2 MAP kinases.

Genatlas:

• MEK2 is serine/threonine protein kinase
• MEK2 plays a critical role in mitogen growth factor signal transduction
• MEK2 activates ERK1 and ERK2 MAP kinases
• MEK2 is dual-specificity kinase that mediate ERK1 and ERK2 activation during adhesion and growth factor signaling (Catalanotti 2009)
• MEK2 has a crucial role in cardiac hypertrophy (Lorenz 2009)
• rucial modulator of Mek and Erk signaling and have potential implications for the role of MAP2K1 and MEK2 in tumorigenesis (Catalanotti 2009)

Homology for human MEK2 (MAP2K2, MKK2)

• homolog to murine Map2k2
• homolog to C.elegans Y54e10bl.6
• homolog to MAP2K1/MEK1

Phenotype Information for MEK2 (MAP2K2, MKK2)

• Gene/Locus: MAP2K2, PRKMK2, MEK2, MKK2
• Phenotype: Cardiofaciocutaneous syndrome

Phenotype Information for MEK2 from OMIM (Online Mendelian Inheritance in Man)