All MDM2 reagents are produced in house and quality controlled, including 28 MDM2 Gene, 2 MDM2 qPCR. All MDM2 reagents are ready to use.
MDM2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MDM2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.