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MDGA2 Protein, Antibody, ELISA Kit, cDNA Clone

MDGA2 Related Areas

MDGA2 Related Pathways

MDGA2 Related Product

    MDGA2 Summary & Protein Information

    MDGA2 Background

    Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential).
    Sequence similarity: Contains 6 Ig-like (immunoglobulin-like) domains.
    Contains 1 MAM domain.
    General information above from UniProt

    Mouse MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2 and MAMDC1, is a cell membrane protein which contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single MAM domain. Biochemical characterization demonstrates that MDGA1 and MDGA2 proteins are highly glycosylated, and that MDGA1 is tethered to the cell membrane by a GPI anchor. The MDGAs are differentially expressed by subpopulations of neurons in both the central and peripheral nervous systems, including neurons of the basilar pons, inferior olive, cerebellum, cerebral cortex, olfactory bulb, spinal cord, and dorsal root and trigeminal ganglia. The similarity of MDGAs to other Ig-containing molecules and their temporal-spatial patterns of expression within restricted neuronal populations, for example migrating pontine neurons and D1 spinal interneurons, suggest a role for these novel proteins in regulating neuronal migration, as well as other aspects of neural development, including axon guidance.

    MDGA2 Alternative Name

    UNQ8188/PRO23197,c14_5286,MAMDC1,MDGA2, [human]
    6720489L24Rik,9330209L04Rik,Mamdc1,Mdga2, [mouse]

    MDGA2 Related Studies

  • Litwack,ED. et al., 2004, Mol Cell Neurosci. 25 (2): 263-74.
  • Hellquist, A. et al., 2009, PLoS One. 4 (12): e8037.
  • Sano,S. et al., 2009, Genesis. 47 (8):505-13.
  • Bucan, M. et al., 2009, PLoS Genet. 5 (6):e1000536.
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