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>Human Cell Expressed
>Human LY86 / MD-16 Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Lymphocyte antigen 86 Protein Datasheet
MD1 / MMD-1 / LY86 Protein Price Inquiry ( Available Sizes )
MD1 / MMD-1 / LY86 Protein Product Information
|Synonym :||LY86, MD1|
A DNA sequence encoding the human LY86 (O95711)(Met1-Ser162) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
MD1 / MMD-1 / LY86 Protein QC Testing
|Purity:||> 85 % as determined by SDS-PAGE||SDS-PAGE:
MD1 / MMD-1 / LY86 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gly 21|
The recombinant human LY86/Fc is a disulfide-linked homodimer. The reduced monomer comprises 383 amino acids and has a predicted molecular mass of 42.7 kDa. The apparent molecular mass of the protein is approximately 48 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
MD1 / MMD-1 / LY86 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
MD1 / MMD-1 / LY86 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|MD-1/Ly86/MD1||Human||MD1 / MMD-1 / LY86 Protein, Recombinant||10242-H02H|
|MD-1/Ly86/MD1||Mouse||MD-1/LY86 Protein, Recombinant||50062-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||MD-1/Ly86/MD1 Antibody, Rabbit MAb||50062-R241|
|WB, ELISA||MD-1 / LY86 Antibody||50062-R416|
|WB, ELISA||Rabbit Polyclonal Antibody||50062-RP02|
MD1 / MMD-1 / LY86 Protein Description
MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105 (RP105) which is a molecule containing leucine-rich repeats and is expressed on B cells, dentritic cells and macrophages, while MD-2 is associated with TLR4. MD-1 is required for efficient RP105 cell surface expression and function. It is indicated that the RP105/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in B cells, and also plays a role in protecting against apoptosis, B-cell proliferation, etc. Mouse MD-1 cDNA encodes a 162 amino acid precursor protein with a putative 19 aa signal peptide and two potential N-linked glycosylation sites. It shares 40% and 66% amino acid sequence identity with chicken and human MD-1 respectively. MD-1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney.
- Miyake K. et al., 1995, J Immunol. 154: 3333-40.
- Miyake K. et al., 1998, J Immunol. 61 (3): 1348-53.
- Miura Y. et al., 1998, Blood. 92: 2815-22.
- Nagai Y. et al., 2002, Blood. 99: 1699-705.
- Hadidi S. et al., 2004, Tissue Antigens. 63 (2): 132-41.
- Tsuneyoshi N. et al., 2005, J Immunol. 174 (1): 340-4.