MCP-3 / CCL7 Protein

Monocyte Chemoattractant Protein 3 / Chemokine (C-C motif) Ligand 7

MCP-3 / CCL7 Products

MCP-3 / CCL7 Protein, Recombinant

Molecule	Species	Description	Cat. No
MCP-3/CCL7	Human	MCP-3/CCL7 Protein, Recombinant	11926-H07E
MCP-3/CCL7	Human	CCL7 / MCP3 Protein, Recombinant	11926-H08E

MCP-3 / CCL7 Gene

Molecule	Species	Description	Cat. No
MCP-3/CCL7	Mouse	CCL7 cDNA Clone / ORF Clone	MG50627-M

MCP-3 / CCL7 Related Areas

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>MCP-3/CCL7

MCP-3 / CCL7 Alternative Names

MCP-3, CCL7, FIC, MARC, MCP3, MGC138463, MGC138465, NC28, SCYA6, SCYA7 [Homo sapiens]

MCP-3, Ccl7, RP23-350G1.4, Scya7, fic, marc, mcp3 [Mus musculus]

MCP-3 / CCL7 Background

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 7(CCL7), also known as MCP-3, is a isform of the C-C chemokine subfamily of the chemokine family which is produced by certain tumor cells and by macrophages. It also own two adjacent N-terminal cysteine residues. Chemokine ligand 7(CCL7) spacifically attracts monocytes, and regulates macrophage function.

MCP-3 / CCL7 Related Studies

1. Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
2. Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8⁺ T cells. Science. 270 (5243): 1811-5.
3. Michalec L, et al. (2002) CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation. The Journal of Immunology. 168: 846-52.
4. Wetzel K,et al. (2007) MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells.International Journal of Cancer. 120(6):1364-71.