MBL-2 / MBL Protein

Mannose-Binding Lectin (protein C) 2 / Mannose-Binding Lectin

MBL-2 / MBL Products

MBL-2 / MBL Protein, Recombinant

Molecule	Species	Description	Cat. No
MBL-2/MBL	Human	MBL-2/MBL Protein,  Recombinant	10405-H07H

MBL-2 / MBL cDNA Clone

Molecule	Species	Description	Cat. No
MBL-2/MBL	Human	Homo sapiens MBL-2/MBL cDNA Clone(NM_000242.2)	HG10405-M
MBL-2/MBL	Mouse	Mus musculus MBL-2/MBL cDNA Clone	MG50063-M

MBL-2 / MBL Related Areas

Immunology>>Adhesion Molecule>>Lectin>>MBL-2/MBL/MBL2

Immunology>>Innate Immunity>>Acute Phase Proteins>>MBL-2/MBL/MBL2

Immunology>>Innate Immunity>>Complement System>>MBL-2/MBL/MBL2

MBL-2 / MBL Alternative Names

MBL2, MBL, MBP, MBP1, COLEC1, HSMBPC, MGC116832, MGC116833 [Homo sapiens]

Mbl2, MBL, L-MBP, MBL-C, MBP-C [Mus musculus]

MBL-2 / MBL Background

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

MBL-2 / MBL Related Studies

1. Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
2. Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
3. Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
4. Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
5. Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.