All Mannan Binding Lectin reagents are produced in house and quality controlled, including 1 Mannan Binding Lectin Antibody, 36 Mannan Binding Lectin Gene, 1 Mannan Binding Lectin IPKit, 3 Mannan Binding Lectin Lysate, 3 Mannan Binding Lectin Protein, 2 Mannan Binding Lectin qPCR. All Mannan Binding Lectin reagents are ready to use.
Recombinant Mannan Binding Lectin proteins are expressed by HEK293 Cells, CHO Cells, CHO Stable Cells with fusion tags as N-mouse IgG1-Fc, N-His, Native.
Mannan Binding Lectinantibodies are validated with different applications, which are WB, IP.
Mannan Binding LectincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Mannan Binding Lectin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: HEK293 Cells
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.