MARK3/C-TAK1

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus

MARK3/C-TAK1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>MARK3/C-TAK1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>MARK3/C-TAK1

MARK3/C-TAK1 Alternative Names

MARK3, C-TAK1, CTAK1, KP78, PAR1A, EMK-2 [Homo sapiens]

Mark3, 1600015G02Rik, A430080F22Rik, ETK-1, ETK1, Emk2, KIAA4230, MPK10, EMK-2 [Mus musculus]

Summaries for MARK3/C-TAK1

Entrez Gene summary for MARK3/C-TAK1:

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene

OMIM - description for MARK3/C-TAK1:

MARK proteins are involved in the specific phosphorylation of microtubule-associated proteins for tau (157140), MAP2 (157130), and MAP4 (157132). MARK3 was originally identified as a marker (KP78) that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas (Parsa, 1988). MARK3 may be involved in cell cycle regulation, and alterations in the MARK3 gene may lead to carcinogenesis.

Wikipedia summary for MARK3/C-TAK1:

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene

Human MARK3/C-TAK1 Protein General Information

 

• Protein names: Recommended name: MAP/microtubule affinity-regulating kinase 3
• Sequence length: 753 AA.
• Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 KA1 (kinase-associated) domain. Contains 1 protein kinase domain. Contains 1 UBA domain.
• Post-translational modification: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity
• Subcellular location: Cell membrane; Peripheral membrane protein
• Tissue specificity: Ubiquitous.

General information above from UniProt

Function for MARK3/C-TAK1 Protein

UniProtKB:

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus

Genatlas:

• kinase involved in the phosphorylation of microtubule-associated proteins
• MARK3/C-TAK1 may be involved in cell cycle regulation, and its alterations may lead to carcinogenesis
• MARK3/C-TAK1 positive regulator of the WNT-beta catenin signaling pathway
• MARK3/C-TAK1 plays a pivotal role in establishing cellular polarity
• with MARK2, phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function
• MARK3/C-TAK1 is potentially a positive regulator for lipogenesis in adipocytes and hepatocytes