MARCO

MARCO is pattern recognition receptor (PRR). MARCO binds Gram-positive and Gram-negative bacteria.

MARCO Related Areas

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker / Scavenger Receptor>>MARCO/SCARA2

Cardiovascular>>Lipid Metabolism>>Scavenger Receptor>>MARCO/SCARA2

MARCO Alternative Names

MARCO, SCARA2 [Homo sapiens]

Marco, Scara2, AI323439, Ly112 [Mus musculus]

Summaries for MARCO

Entrez Gene summary for MARCO:

The protein encoded by this MARCO gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. MARCO may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. MARCO may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

Wikipedia summary for MARCO:

Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene.

Human MARCO Protein General Information

 

• Protein names: Macrophage receptor MARCO
• Sequence length: 520 AA.
• Sequence similarities: MARCO contains 1 collagen-like domain. MARCO contains 1 SRCR domain.
• Subunit structure: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands
• Subcellular location: Membrane; Single-pass type II membrane protein

General information above from UniProt

Function for MARCO Protein

UniProtKB:

MARCO is pattern recognition receptor (PRR). MARCO binds Gram-positive and Gram-negative bacteria.

Genatlas:

• MARCO plays a role in innate immune response

Homology for human MARCO

• homolog to murine Marco