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MARCO Protein, Antibody, ELISA Kit, cDNA Clone

MARCO  Related Areas

MARCO  Related Pathways

MARCO  Related Product

    MARCO  Summary & Protein Information

    MARCO  Background

    Gene Summary: The protein encoded by this MARCO gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. MARCO may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. MARCO may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subunit structure: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (By similarity).
    Subcellular location: Membrane; Single-pass type II membrane protein (Probable).
    Sequence similarity: Contains 1 collagen-like domain.
    Contains 1 SRCR domain.C
    General information above from UniProt

    Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type I I membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic position of MARCO-expressing cells in lymphoid organs suggests an important role for this bacteria-binding molecule in removal of pathogens. MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 270-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain. It is possible that cooperation between the SRCR domain and the collagenous domain is needed for high-affinity bacterial binding, or that the SRCR domain has to be in a trimeric form to effectively bind to bacteria

    MARCO  Alternative Name

    MARCO,SCARA2, [human]
    AI323439,Ly112,Marco,Scara2, [mouse]

    MARCO  Related Studies

  • Kraal, G. et al., 2000, Microbes Infect . 2 (3): 313-6.
  • Sankala, M., 2002, J Biol Chem. 277 (36): 33378-85.
  • Arredouani, MS., 2004, Cell Mol Biol. 50 Online Pub : OL657-65.
  • Thakur, SA., 2009, Toxicol Sci. 107 (1): 238-46.
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