0 products, total $0.+86-400-890-9989      Login |  Register 中文한국어

Browse By Molecule:

Your Position: Home > MAPT / PHF-tau Protein

MAPT / PHF-tau Protein

Microtubule-associated protein tau

MAPT / PHF-tau Products

MAPT / PHF-tau Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat No
MAPT / PHF-tau Human MAPT / Tau Protein, Recombinant 10058-H07E

MAPT / PHF-tau cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat No
MAPT / PHF-tau Human Human Tau transcript variant 4 Gene cDNA Clone / ORF Clone HG10058-M

MAPT / PHF-tau Alternative Names

microtubule-associated protein tau, MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau [Homo sapiens]

microtubule-associated protein tau, Mapt, RP23-136D4.1, AI413597, AW045860, Mtapt, Tau, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau [Mus musculus]

MAPT / PHF-tau Background

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

MAPT / PHF-tau Related Studies

  1. Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91.
  2. Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62.
  3. Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26.

 

MAPT (PHF-tau) related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
_×