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>Human p38 alpha / MAPK14 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Mitogen-activated protein kinase 14 Protein Datasheet
MAPK14 / p38 alpha Protein Price Inquiry ( Available Sizes )
MAPK14 / p38 alpha Protein Product Information
|Synonym :||MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A|
A DNA sequence encoding the human MAPK14 isoform 2 (NP_620581.1) (Met1-Ser360) was fused with a polyhistide tag at the N-terminus.
|Expression Host:||Baculovirus-Insect cells|
MAPK14 / p38 alpha Protein QC Testing
|Purity:||> 90% as determined by SDS-PAGE||SDS-PAGE:
MAPK14 / p38 alpha protein
|Kinase activity untested|
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||His|
The recombinant human MAPK14 consists of 378 amino acids and has a calculated molecular mass of 43.7 kDa. The recombinant protein migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile 20mM Tris, 500mM NaCl, pH7.4, 10%gly.
MAPK14 / p38 alpha Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
MAPK14 / p38 alpha Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|p38 alpha/MAPK14||Human||MAPK14 / p38 alpha Protein, Recombinant||10081-H07B|
|p38 alpha/MAPK14||Human||p38 alpha/MAPK14 Protein, Recombinant||10081-H08B|
|p38 alpha/MAPK14||Human||p38 alpha/MAPK14 Protein, Recombinant||10646-H07B|
|p38 alpha/MAPK14||Human||p38 alpha/MAPK148 Protein, Recombinant||10646-HNCB|
MAPK14 / p38 alpha Protein Description
Mitogen-activated protein (MAP) kinases are intracellular serine/threonine kinases activated by dual phosphorylation of adjacent threonine and tyrosine, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Human p38 MAP kinase, also known as MAPK14, is activated following exposure to products of microbial pathogens, physical-chemical stimuli and cytokines. Either its autophosphorylation triggered by the interaction with MAP3K7IP1/TAB1 protein, or phosphorylation by MAP kinase kinases (MKKs) is requisite for activation of MAPK14/p38 alpha. It transduces signals by phosphorylating a number of downstream molecules including transcription factors ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, as well as tumor suppressor p53. p38 thus exists as an important regulator of both embryonic development and cancer progression. Four alternatively spliced transcript variants have been reported, and MAPK14/p38 alpha of 360 amino acids is the best characterized isoform. Furthermore, the MAPK14/p38 alpha has been suggested to play a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression.
- Han J. et al., 1995, Biochim Biophys Acta. 1265: 224-7.
- Ben-Levy R. et al., 1998, Curr Biol. 8: 1049-57.
- Tamura K. et al., 2000, Cell. 102: 221-31.
- Bradham C. et al., 2006, Cell Cycle. 5: 824-8.