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p38 delta/MAPK13

p38 delta/MAPK13 Protein & Antibody

MAPK13 Related Information

Entrez Gene Summary for p38 delta/MAPK13


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

OMIM-Description for p38 delta/MAPK13


Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses. The stress-activated protein kinases (SAPKs; see 601335) are MAPKs that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. By screening a pituitary gland library with a partial SAPK2b (p38-beta; 602898) cDNA, Goedert et al. (1997) isolated cDNAs encoding a protein that they designated SAPK4. The sequence of the predicted 365-amino acid protein is approximately 60% identical to those of SAPK3 (p38-gamma; 602399), SAPK2a (p38; 600289), and SAPK2b. Like those SAPKs, SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines. MKK6 (601254) was found to be the major upstream activator of SAPK4. Goedert et al. (1997) reported that the substrate specificity of SAPK4 in vitro was similar to that of SAPK3. Northern blot analysis revealed that SAPK4 is expressed as a 2.3-kb transcript in a variety of tissues. Kumar et al. (1997) and Wang et al. (1997) also isolated SAPK4 cDNAs. Using Northern blot analysis, Wang et al. (1997) compared the expression patterns of SAPK4 (designated p38-delta by them), SAPK2a, SAPK2b, and SAPK3 in 50 human tissues. They detected 2 SAPK4 transcripts: a predominant 1.8-kb mRNA and a lower abundance 6-kb mRNA. The highest levels of expression were observed in exocrine/endocrine tissues including salivary gland, pituitary gland, adrenal gland and placenta. Wang et al. (1997) determined that mutagenesis of the threonine and tyrosine residues in the TGY motif abolished the kinase activity of SAPK4 and blocked activation by UV light or MKK6. Thus, like other MAPKs, SAPK4 requires phosphorylation at either or both of these residues for activation.

.zh=p38 delta/MAPK13


Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

p38 delta/MAPK13 Alternative Names

SAPK4,PRKM13,MAPK13,MAPK-13,p38delta, [homo-sapiens]
MAPK13,MGC99536,p38 delta,p38delta,PRKM13,RP1-179N16.4,SAPK4, [human]
Mapk13,p38 delta,RP24-313J18.2,SAPK4,Serk4, [mouse]
SAPK4,Serk4, [mus-musculus]

p38 delta/MAPK13 Related Products

p38 delta/MAPK13 Proteins

Product nameProduct name
Human p38 delta / MAPK13 Protein (GST Tag)Human p38 delta / MAPK13 Protein (Activated in vitro, GST Tag)

p38 delta/MAPK13 Antibodies

Product nameProduct name
p38 delta / MAPK13 Antibody, Rabbit PAbp38 delta / MAPK13 Antibody, Rabbit PAb, Antigen Affinity Purified

p38 delta/MAPK13 cDNA Clones

Product nameProduct name
Mouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-HA tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-His tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-Flag tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-His tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-Flag tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmidHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-Flag tagHuman p38 delta/MAPK13 Gene ORF cDNA clone in cloning vectorMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-HA tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-Myc tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-HA tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-His tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-His tagMouse p38 delta/MAPK13 Gene ORF cDNA clone in cloning vectorMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmidMouse p38 delta/MAPK13 Gene ORF cDNA clone expression plasmid, N-HA tag

p38 delta/MAPK13 ELISA

Product nameProduct name
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