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p38 delta/MAPK13

p38 delta/MAPK13 Protein & Antibody

MAPK13 Related Information

p38 delta/MAPK13N


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

OMIM-Description for p38 delta/MAPK13N


Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses. The stress-activated protein kinases (SAPKs; see 601335) are MAPKs that are activated by chemical and environmental stresses as well as by proinflammatory cytokines. By screening a pituitary gland library with a partial SAPK2b (p38-beta; 602898) cDNA, Goedert et al. (1997) isolated cDNAs encoding a protein that they designated SAPK4. The sequence of the predicted 365-amino acid protein is approximately 60% identical to those of SAPK3 (p38-gamma; 602399), SAPK2a (p38; 600289), and SAPK2b. Like those SAPKs, SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines. MKK6 (601254) was found to be the major upstream activator of SAPK4. Goedert et al. (1997) reported that the substrate specificity of SAPK4 in vitro was similar to that of SAPK3. Northern blot analysis revealed that SAPK4 is expressed as a 2.3-kb transcript in a variety of tissues.

p38 delta/MAPK13


Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene

p38 delta/MAPK13 Alternative Names

MAPK13,MGC99536,p38 delta,p38delta,PRKM13,RP1-179N16.4,SAPK4, [human]
Mapk13,p38 delta,RP24-313J18.2,SAPK4,Serk4, [mouse]

p38 delta/MAPK13 Related Products

p38 delta/MAPK13 Proteins

Product nameProduct name
Human p38 delta / MAPK13 Protein (Activated in vitro, GST Tag)Human p38 delta / MAPK13 Protein (GST Tag)

p38 delta/MAPK13 Antibodies

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p38 delta/MAPK13 cDNA Clones

Product nameProduct name
Mouse MAPK13 Gene cDNA Clone (full-length ORF Clone)Mouse MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedMouse MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedMouse MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedMouse MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedMouse MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedHuman MAPK13 Gene cDNA Clone (full-length ORF Clone)Human MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedHuman MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedHuman MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHuman MAPK13 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedHuman MAPK13 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged

p38 delta/MAPK13 ELISA

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"