MAP1D

MAP1D removes the N-terminal methionine from nascent proteins. MAP1D may play a role in colon tumorigenesis.

MAP1D Related Areas

Enzyme>>Protease & Regulator>>Other Proteases>>MAP1D

MAP1D Alternative Names

MAP1D, CDS of metAP-3 within PCR fragment [Homo sapiens]

Summaries for MAP1D

OMIM - description for MAP1D:

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003).

Human MAP1D Protein General Information

 

• Protein names: Methionine aminopeptidase 1D, mitochondrial
• Sequence length: 335 AA.
• Sequence caution: The sequence AAY55948.1 differs from that shown. Reason: Erroneous initiation.
• Sequence similarities: MAP1D belongs to the peptidase M24A family.
• Caution: It is uncertain whether Met-1 or a Met upstream of this sequence is the initiator.
• Cofactor: MAP1D binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. MAP1D is also active with zinc, manganese or divalent iron ions
• Subcellular location: Mitochondrion
• Tissue specificity: Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level).
• Biophysicochemical properties: Kinetic parameters:
  KM=573 µM for Met-pro-p-nitroanilide (at pH 8)
  pH dependence:
  Optimum pH is 7.5-8.0.

General information above from UniProt

Function for MAP1D Protein

UniProtKB:

MAP1D removes the N-terminal methionine from nascent proteins. MAP1D may play a role in colon tumorigenesis.

Genatlas:

• MAP1D catalizes N-terminal methionine removal, an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins
• MAP1D may play an important role in colon tumorigenesis