MANF

MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. MANF modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

MANF Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>MANF/ARMET

MANF Alternative Names

MANF, ARMET, ARP, MGC142148, MGC142150 [Homo sapiens]

Manf, Armet, 3230402M22Rik, AA407711, AA408789, AA673178, D17914, D18Mgi17 [Mus musculus]

Summaries for MANF

Entrez Gene summary for MANF:

The protein encoded by this MANF gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. MANF was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010]

Wikipedia summary for MANF:

Mesencephalic astrocyte-derived neurotrophic factor is a protein that in humans is encoded by the MANF gene.
This MANF gene encodes a highly conserved protein whose function is not yet known. With the protein size correction, this codon is now identified as the initiation codon.

Human MANF Protein General Information

 

• Protein names: Mesencephalic astrocyte-derived neurotrophic factor
• Sequence length: 182 AA.
• Domain: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
• Sequence similarities: MANF belongs to the ARMET family.
• Post-translational modification: MANF may contain sialic acid residues.
• Induction: By endoplasmic reticulum stress.
• Subcellular location: Secreted
• Caution: MANF was originally thought to be much longer and included an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is now thought to be the 5'-UTR of the mRNA. It is uncertain whether Met-1 or Met-4 is the initiator.
• Sequence caution: The sequence AAB08753.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
  The sequence AAI13589.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
  The sequence AAI13591.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

General information above from UniProt

Function for MANF Protein

UniProtKB:

MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. MANF modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Genatlas:

• MANF may be involved in oncogenesis
• MANF selectively promotes the survival of dopamine neurons of the ventral midbrain (Pubmed 16462600)
• ER stress E-II-dependent gene that likely contributes to quality control of proteins in the ER (Pubmed 17507765)
• MANF is a secreted mediator of the adaptive pathway of unfolded protein response (Pubmed 18561914)
• cerebral ischemia-induced MANF expression may be protective to the neurons (Pubmed 19773801)
• when expressed intracellularly, MANF can efficiently protect the apoptotic neurons (Pubmed 21047780)
• MANF plays an important role in protection of neurodegenerative, apoptotic, and stress conditions, which thereby makes it a highly potential therapeutic agent (Pubmed 21047780)