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>Human Cell Expressed
>Human MAG / GMA / Siglec-4 Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Myelin associated glycoprotein Protein Datasheet
MAG / GMA Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
MAG / GMA Protein Product Information
|Synonym :||MAG, GMA|
A DNA sequence encoding the human MAG (P20916-1) (Met1-Pro516) was expressed with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
MAG / GMA Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
MAG / GMA protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gly 20|
The recombinant human MAG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 738 amino acids and has a predicted molecular mass of 81.7 kDa. The apparent molecular mass of the protein is approximately 113 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
MAG / GMA Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
MAG / GMA Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|MAG||Human||MAG / GMA Protein, Recombinant||13186-H02H|
|MAG||Human||MAG / GMA Protein, Recombinant||13186-H08H|
MAG / GMA Protein Description
The myelin-associated glycoprotein (MAG) is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. MAG contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.
- Quarles RH. 2007, J Neurochem. 100 (6): 1431-48.
- Mukhopadhyay G. et al., 1994, Neuron. 13 (3): 757-67.
- Barton DE. et al., 1987, Genomics. 1 (2): 107-12.