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MAG/GMA/Siglec-4  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
13186-H08H-50
13186-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
13186-H02H-100
13186-H02H-200
100 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
51398-M08H-20
51398-M08H-100
20 µg 
100 µg 
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Expression host: Human Cells  
    51398-M02H-20
    51398-M02H-100
    20 µg 
    100 µg 
    Add to Cart

    MAG/GMA/Siglec-4 Related Pathways

    MAG/GMA/Siglec-4 Summary & Protein Information

    MAG/GMA/Siglec-4 Background

    Gene Summary: Spagnol et al. (1989) found that MAG cDNA clones isolated from a human brain cDNA library had an open reading frame of 1,878 nucleotides encoding a peptide of 626 amino acids with a calculated molecular weight of 69.1 kD.
    General information above from NCBI
    Subunit structure: Binds to RTN4R (By similarity).
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Sequence similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    General information above from UniProt

    The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.

    MAG/GMA/Siglec-4 Alternative Name

    GMA,S-MAG,SIGLEC4A,SIGLEC-4A, [homo-sapiens]
    GMA,SIGLEC-4A,SIGLEC4A,S-MAG, [human]
    Gma,MGC123387,siglec-4a, [mouse]
    Gma,siglec-4a, [mus-musculus]

    MAG/GMA/Siglec-4 Related Studies

  • Quarles RH. (2007) Myelin-associated glycoprotein (MAG): past, present and beyond. J Neurochem. 100(6):1431-48.
  • Mukhopadhyay G, et al. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13(3): 757-67.
  • Barton DE, et al. (1987) The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. Genomics. 1(2): 107-12.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"