MAD2L1 (MAD2)

MAD2L1 may function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

MAD2L1 (MAD2) Related Areas

 

MAD2L1 (MAD2) Alternative Names

MAD2L1, MAD2, HSMAD2 [Homo sapiens]

Mad2l1, MAD2, AA673185, MGC113763 [Mus musculus]

Summaries for MAD2L1 (MAD2)

Entrez Gene summary for MAD2L1:

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

Wikipedia summary for MAD2L1 (MAD2):

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Human MAD2L1 (MAD2) Protein General Information

 

• Protein names: MAD2L1-binding protein
• Sequence length: 274 AA.
• Developmental stage: During the cell cycle, levels increase and then remain constant until late mitosis after which they drop.
• Sequence similarities: MAD2L1 belongs to the MAD2L1BP family.
• Post-translational modification: Phosphorylated upon DNA damage, probably by ATM or ATR
• Subunit structure: Interacts with MAD2L1.
• Subcellular location: Nucleus. Cytoplasm › cytoskeleton › spindle. Note: During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
• Sequence caution: The sequence BAG59665.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for MAD2L1 (MAD2) Protein

UniProtKB:

MAD2L1 may function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

Genatlas:

• MAD2L1 is involved in the cell cycle control at mitotic spindle assembly checkpoint
• MAD2L1 prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate
• tumor suppressor gene also required for somatic cell viability (loss of MAD2 causing pemature CCNB1 degradation and mitotic failure in somatic cells)
• MAD2L1 is involved in the mitotic spindle checkpoint pathway (Pubmed 17498870)
• MAD2L1 acts in a surveillance mechanism that mediates a metaphase delay in response to nonexchange chromosomes
• MAD2L1 is required for CDC20 to form a complex with BUB1B (Pubmed 18997788)
• MAD2L1 might play an important role in the development of gastric cancer and silencing the MAD2L1 gene may help to deal with the multidrug resistance of gastric cancer cells (Pubmed 20440596)
• MAD2L1-containing complexes are removed in stages during mitotic progression (Pubmed 21335556)
• possible differential regulation of different MAD2L1-containing complexes during checkpoint inactivation (Pubmed 21335556)
• MAD2L1's overexpression is a critical mediator of the chromosome instability observed upon inactivation of two major tumor suppressor pathways (Pubmed 21665145)

Homology for human MAD2L1 (MAD2)

• homolog to mitotic arrest deficient yeast
• homolog to murine Mad2l1