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M-CSF / CSF-1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human MCSF/CSF1 Antibody Product Information
Immunogen:Recombinant Human M-CSF / CSF-1 protein (Catalog#11792-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human M-CSF / CSF-1 (rh M-CSF / CSF-1; Catalog#11792-H08H; P09603-1; Met 1-Asn 190). M-CSF / CSF-1 specific IgG was purified by Human M-CSF / CSF-1 affinity chromatography.
Human MCSF/CSF1 Antibody Usage Guide
Specificity:Human M-CSF / CSF-1
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CSF1. The detection limit for Human CSF1 is approximately 0.00975 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
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              M-CSF/CSF-1 Background

              Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

              Human M-CSF/CSF-1 References
              1. Pandit J. et al., 1992, Science. 258: 1358-62.
              2. Tokai M. et al., 2000, J Bacteriol. 182 (10): 2865-8.
              3. Fan X. et al., 2001, Am J Physiol Endocrinol Metab. 280 (1): E103-11.
              4. Frangogiannis NG. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92.
              5. Cupp JS. et al., 2007, Am J Surg Pathol. 31 (6): 970-6.
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              Catalog: 11792-RP02-200
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              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"