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Lysosomal Enzymes

To accomplish the tasks associated with digestion, the lysosomes use some 40 different types of lysosomal enzymes, such as glycosidases, protease, acid phosphatases, sulfatases and lipases. Lysosomal enzymes are synthesized in the endoplasmic reticulum and modified in the Golgi apparatus. Lysosomal enzymes are tagged for lysosomes by the addition of mannose-6-phosphate label. A deficiency of any one of these lysosomal enzymes will lead to lysosomal storage diseases, such as Tay-Sachs disease and Pompe's disease. Lysosomal enzymes are also known to be involved in cancer processes.

Sino Biological offers a comprehensive set of tools for research on lysosomal enzymes, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.

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Lysosomal Enzymes Background

Lysosomes are membrane-bounded organelles which act as the "garbage disposal" of the cell. Lysosomes are found in all eukaryotic cells, but are most numerous in disease-fighting cells, such as leukocytes. Lysosomes digest foreign macromolecules and engulfed viruses and bacteria presenting in phagosomes. Lysosomes also break down cell components that are no longer needed. While lysosomes digest some materials in this process, it is actually accomplished through programmed cell death, called apoptosis. Lysosomes break down cellular waste products, fats, carbohydrates, proteins, and other macromolecules into simple compounds, which are then returned to the cytoplasm as new cell-building materials. To accomplish the tasks associated with digestion, the lysosomes use some 40 different types of lysosomal enzymes, such as glycosidases, protease, acid phosphatases, sulfatases and lipases. Lysosomal enzymes are synthesized in the endoplasmic reticulum and modified in the Golgi apparatus. Lysosomal enzymes are tagged for lysosomes by the addition of mannose-6-phosphate label. A deficiency of any one of these lysosomal enzymes will lead to lysosomal storage diseases, such as Tay-Sachs disease and Pompe's disease. Lysosomal enzymes are also known to be involved in cancer processes.

Lysosomal Enzymes References

    1. Levicar N, et al. (2002) Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol. 58(1):21-32.
    2. Efremov AV, et al. (2007) [Role of lysosomal enzymes in the genesis of major clinical and pathophysiological syndromes: facts and hypotheses] Patol Fiziol Eksp Ter. (1):18-21.
    3. Korolenko TA, et al. (2008) Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis. Bull Exp Biol Med. 145(5):560-3.