Lyn Protein

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Lyn Products

Lyn Protein, Recombinant

Molecule	Species	Description	Cat. No
Lyn	Human	Lyn Protein, Recombinant, With GST Tag	10829-H09B

Lyn cDNA Clone

Molecule	Species	Description	Cat. No
Lyn	Human	Homo sapiens Lyn cDNA Clone	HG10829-M

Lyn Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Src (sarcoma) Family Kinase>>Lyn

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Src (sarcoma) Family Kinase>>Lyn

Immunology>>Adaptive Immunity>>B Cell>>Lyn

Lyn Alternative Names

LYN, FLJ26625, JTK8 [Homo sapiens]

Lyn, RP23-49A12.2, AA407514, Hck-2 [Mus musculus]

Lyn Background

Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may down regulate expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. Lyn kinase also acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Lyn kinase relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. This kinase is Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. In a word, Lyn kinase functions primarily as negative regulator, but can also function as activator, depending on the context. Tyrosine-protein kinase Lyn Required for the initiation of the B-cell response, but also for its down-regulation and termination. It also Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. It has been reported that Lyn kinase plays a role in the inflammatory response to bacterial lipopolysaccharide. Lyn kinase Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils.

Lyn Related Studies

1. Grishin A V, et al. (2001) Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proc Natl Acad Sci U.S.A. 98 (18): 10172–7.
2. Hayashi T, et al. (1999) The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature. 397(6714): 72-6.
3. Ptasznik A, et al. (2004) Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells. Nat Med. 10(11): 1187-9.