- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Ly108 / SLAMF6 Antibody Datasheet
|Order or Inquire for Ly108 / SLAMF6 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.039 ng/well in ELISA|
Ly108 / SLAMF6 Antibody Product Information
Recombinant Human Ly108 / SLAMF6 protein (Catalog#11945-H08H)
|Antibody Type :||Mouse Monoclonal Antibody ( Mouse mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Ly108 / SLAMF6 (rh Ly108 / SLAMF6; Catalog#11945-H08H; Q96DU3-1; Met 1-Met 226). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatograph.
Ly108 / SLAMF6 Antibody Usage Guide
Human Ly108 / SLAMF6
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
|Direct ELISA :||This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human SLAMF6. The detection limit for Human SLAMF6 is approximately 0.039 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Ly108 / SLAMF6 Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Ly108/SLAMF6||Human||Ly108/SLAMF6 Protein, Recombinant||11945-H08H|
|Ly108/SLAMF6||Mouse||Ly108/SLAMF6 Protein, Recombinant||50275-M08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human Ly108/SLAMF6||WB, ELISA||Ly108 / SLAMF6 Antibody (Antigen Affinity Purified)||11945-RP02|
|Human Ly108/SLAMF6||ELISA||Ly108 / SLAMF6 Antibody||11945-MM08|
|Mouse Ly108/SLAMF6||WB, ELISA||Ly108 / SLAMF6 Antibody||50275-RP01|
|Mouse Ly108/SLAMF6||WB, ELISA||Ly108 / SLAMF6 Antibody (Antigen Affinity Purified)||50275-RP02|
Ly108 / SLAMF6 Antibody Background
SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains oneIg-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
- Gray CW, et al., 2000, Eur. J. Biochem.267 (18): 5699-710.
- Bottino C, et al., 2001,J Exp Med. 194 (3): 235-46.
- Valdez PA, et al., 2004,J. Biol. Chem.279 (18): 18662-9.
- Claus M, et al., 2007, Front. Biosci.13: 956-65.