Lupus Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
IL12A/IL-12A	P35, IL12A, CLMF, NFSK, NKSF1	Interleukin 12 (IL12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a 70 kDa disulfide-linked heterodimeric cytokine composed of a 35-kD subunit P35 and a 40-kD subunit P40, also designated as IL12A and IL12B. IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed.	10021-H02H		HG10021-M
IL12B/IL-12B	IL12B, CLMF, CLMF2, NKSF, NKSF2	A large excess of monomeric IL12B is secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.	10052-H02H, 10052-H08H	10052-MM01, 10052-RP02, 10052-RP03	HG10052-M
MIF					HG10246-M, MG50066-M
BLyS/TNFSF13B	BAFF, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4	Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), also known as B-Lymphocyte Stimulator (BLyS), B cell-activating factor (BAFF), and CD257, which is a single-pass type II membrane protein. TNFSF13B is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). It also acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.	10056-H01H		HG10056-M
IL-10	CSIF, TGIF, IL10, IL10A, MGC126450, MGC126451				HG10947-M, MG50245-M
CD40L/CD154	CD40LG,IGM, IMD3, TRAP, gp39, HIGM1, T-BAM, TNFSF5, hCD40L				HG10239-M
IFNA4	MGC142200	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily. IFNA acts as a pyrogenic factor and thus causes fever by binding to opioid receptors and eliciting the release of prostaglandin-E2, and serves as an analgesic by employing the similar mechanism. Furthermore, IFNA is suggested to promote apoptosis and accordingly has therapeutic effect against certain cancers by inducing increased production of the p53 gene product.	10336-H01H		HG10336-M
IFNA5	RP11-380P16.5	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily. IFNA acts as a pyrogenic factor and thus causes fever by binding to opioid receptors and eliciting the release of prostaglandin-E2, and serves as an analgesic by employing the similar mechanism. Furthermore, IFNA is suggested to promote apoptosis and accordingly has therapeutic effect against certain cancers by inducing increased production of the p53 gene product.	10342-H01H		HG10342-M
IFNA7	IFNA-J				HG10341-M
IFNA8	IFNαB2				HG10347-M
IFNA10	MGC119878,  MGC119879				HG10349-M