Anti-Lumican Antibody

Cat: 11640-RP01
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All Lumican Reagents
Anti-Lumican Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Lumican Antibody
Validated applications
Species reactivity
Reacts with: Human
Human Lumican
Recombinant Human LUM protein (Catalog#11640-H08H)
Produced in rabbits immunized with purified, recombinant Human LUM (rh LUM; Catalog#11640-H08H; NP_002336.1; Met 1-Asn 338). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Lumican Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Lumican Antibody Alternative Names
Anti-LDC Antibody;Anti-SLRR2D Antibody
Lumican Background Information

Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major component of the cornea, dermal, and muscle connective tissues. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. lumican expressed in injured epithelium may modulate cell behavior such as adhesion or migration, thus contributing to corneal epithelial wound healing. Lumican plays a crucial role in the regulation of collagen assembly into fibrils in various connective tissues and serve as a definitive link between a necessity for lumican in the development of a highly organized collagenous matrix and corneal transparency.

Full Name
  • Saika S, et al. (2000) Role of lumican in the corneal epithelium during wound healing. J Biol Chem. 275(4): 2607-12.
  • Chakravarti S, et al. (1998) Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol. 141(5): 1277-86.
  • Ezura Y, et al. (2000) Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. J Cell Biol. 151(4): 779-88.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Lumican Antibody Rabbit Monoclonal FCM,ICC/IF,IF 11640-R077
    Anti-Lumican Antibody Rabbit Polyclonal ELISA 11640-T16
    Anti-Lumican Antibody Rabbit Monoclonal ELISA 11640-R110
    Anti-Lumican Antibody Rabbit Monoclonal ICC/IF,IF 11640-R212
    Anti-Lumican Antibody Rabbit Polyclonal ELISA 11640-RP02
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