All LBP reagents are produced in house and quality controlled, including 1 LBP Antibody, 12 LBP Gene, 1 LBP Lysate, 1 LBP Protein, 1 LBP qPCR. All LBP reagents are ready to use.
Recombinant LBP proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-His.
LBPantibodies are validated with different applications, which are ELISA.
LBPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LBP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and to purified aggregates of extracted endotoxin, and catalyses the delivery of endotoxin to membrane ( mCD14,GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to endotoxin. LBP efficiently catalyses the transfer of individual molecules of endotoxin to (s)CD14 only when LBP–endotoxin aggregates are formed in the presence of albumin. In the presence of EDTA, LBP binding promotes further disaggregation of endotoxin. LBP binding does not have such drastic effects under more physiological conditions, but may still induce more subtle topological rearrangements of endotoxin.