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Lipopolysaccharide binding protein/LBP Protein, Antibody, ELISA Kit, cDNA Clone

Lipopolysaccharide binding protein/LBP Related Areas

Lipopolysaccharide binding protein/LBP Related Pathways

Lipopolysaccharide binding protein/LBP Related Product

    Lipopolysaccharide binding protein/LBP Background

    Gene Summary: The protein encoded by this LBP gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that LBP is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. LBP is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
    General information above from NCBI
    Subunit structure: When bound to LPS, interacts (via C-terminus) with soluble CD14.
    Subcellular location: Secreted.
    Sequence similarities: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.C
    General information above from UniProt

    Lipopolysaccharide binding protein ( LBP ) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides ( LPSs ). LBP binds directly to the outer membrane of Gram-negative bacteria and to purified aggregates of extracted endotoxin, and catalyses the delivery of endotoxin to membrane ( mCD14,GPI-Linked ) and soluble ( sCD14 ) forms of CD14, thereby markedly increasing host cell sensitivity to endotoxin. LBP efficiently catalyses the transfer of individual molecules of endotoxin to (s)CD14 only when LBP–endotoxin aggregates are formed in the presence of albumin. In the presence of EDTA, LBP binding promotes further disaggregation of endotoxin. LBP binding does not have such drastic effects under more physiological conditions, but may still induce more subtle topological rearrangements of endotoxin.

    Lipopolysaccharide binding protein/LBP Altermative Names

    Lipopolysaccharide binding protein/LBP Related Studies

  • J. Weiss, 2003, Biochemical Society Transactions: Volume 31, part 4: 785-790.
  • RR Schumann, et al., Science, 1990, Vol 249, Issue 4975: 1429-143.
  • Carsten J. Kirschning, et al., 1997, Genomics, Volume 46, Issue 3: 416-25.
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